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KMID : 0043320150380010018
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Archives of Pharmacal Research
2015 Volume.38 No. 1 p.18 ~ p.25
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Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.
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Mun Bo-Ra
Wang Weihong
Kim Hi-Young
Hahn Dong-Yup
Yang In-Ho
Won Dong-Hwan
Kim Eun-Hee
Lee Ji-Hye
Han Chul-Kyeong
Kim Hyun-Ji
Ekins Merrick
Nam Sang-Jip
Choi Hyuk-Jae
Kang Heon-Joong
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Abstract
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Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4?7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3?7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.
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KEYWORD
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5α, 8α-epidioxy sterol, Monanchora sp., Cytotoxicity, Pancreatic cancer, Renal cancer, Colorectal cancer
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